Insulin Resistance: Mechanism, Risks, and Strategies for Reversal 🔬 Introduction Insulin resistance is a metabolic condition where cells fail to respond effectively to insulin, leading to elevated blood glucose and insulin levels. It is a precursor to type 2 diabetes, cardiovascular disease, and other chronic conditions. Fortunately, it is often reversible with timely lifestyle and therapeutic interventions. ⚙️ Mechanism of Insulin Resistance Insulin resistance develops due to: • Ectopic fat accumulation in liver and muscle cells • Chronic inflammation and oxidative stress • Disruption of insulin signaling pathways (e.g., PI3K/Akt, MAPK) • Endoplasmic reticulum stress in adipocytes and hepatocytes[1] 🧪 Insulin Resistance Symptoms and Diagnosis Symptom Description Fatigue Reduced glucose uptake by cells Acanthosis nigricans Dark patches on skin Weight gain Especially abdominal fat Irregular cycles In women, linked to PCOS Blurred vision Due to fluctuating glucose levels Diagnostic te...
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