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Understanding Metformin: Mechanism of Action, Clinical Uses, and Safety Profile

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Understanding Metformin: Mechanism of Action, Clinical Uses, and Safety Profile Infographic Overview Metformin is one of the most widely prescribed oral antidiabetic drugs globally. Known for its efficacy and safety, it plays a central role in managing Type 2 Diabetes Mellitus. In this post, we’ll explore its pharmacological mechanism, clinical applications, and safety considerations. 1. Mechanism of Action Metformin primarily acts by reducing hepatic glucose production (gluconeogenesis). It enhances insulin sensitivity and increases peripheral glucose uptake. Unlike sulfonylureas, it does not stimulate insulin secretion, which reduces the risk of hypoglycemia. Activates AMP-activated protein kinase (AMPK) Decreases intestinal absorption of glucose Improves insulin receptor activity 2. Clinical Uses Metformin is the first-line therapy for: Type 2 Diabetes Mellitus Polycystic Ovary Syndrome (PCOS) Insulin resistance in obese patients It is often used in combination with other antidiabet...
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Recent Major Updates in Pharmaceutical Industry

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Recent Major Updates In Pharmaceutical Industry

1. Sanofi's New Polio Vaccine Approval in India:

   - Sanofi has received approval for a new injectable polio vaccine (IPV) called IMOVAX-Polio in India. This comes after the company ceased production of its ShanIPV vaccines in India, which raised concerns about potential shortages in the country's IPV supply.

#Recent-updates-in-pharmaceutical-industry

2. Global Private Equity Firms Eyeing Bharat Serums and Vaccines (BSV):

Five global private equity firms, including Warburg Pincus, Permira, EQT, Bain, and TPG, are interested in bidding for Bharat Serums and Vaccines (BSV). The Mumbai-based biopharmaceutical company is seeking over $1 billion. Advent International, the current owner, acquired BSV in 2019 and now plans to sell it¹.

3. Collaboration for Oral Polio Vaccines Production:

Bharat Biotech has collaborated with the Netherlands-based **Bilthoven Biologicals B.V., a wholly-owned arm of Serum Institute of India, to strengthen the production and supply security of oral polio vaccines (OPVs) within India and globally.

4. Lupin's New Chief Quality Officer:

Dr. Ranjana Pathak has been appointed as Lupin's chief quality officer, succeeding Johnny Mikell. Dr. Pathak brings 30 years of experience in quality management from her previous roles at Cipla, Watson/Actavis, and Endo Pharmaceuticals.

5. Strategic Focus on the Indian Market by Sanofi:

   - Sanofi is prioritizing the Indian market, with a focus on areas such as diabetes, consumer health, and innovation. Under new leadership, they plan to launch one or two products in India every year.

6. India's Return to Penicillin G Production:

After three decades, India is set to make Penicillin G again, driven by the government's Production-Linked Incentive (PLI) push.

These updates reflect the dynamic nature of the pharmaceutical industry, where companies are constantly innovating, collaborating, and adapting to meet global healthcare needs.

References:

(1) Pharmaceuticals Industry: Get latest Pharma Industry News, Top

(2) Top 10 Pharmaceutical Industry Trends in 2024 | StartUs Insights

(3) Six new pharmaceutical industry trends | McKinsey. gy.

(4) Pharma breakthroughs: 10 novel drug approvals that made headlines in ...

(5) en.wikipedia.org. .

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